Treatment of neuroblastoma and rhabdomyosarcoma using RGD-modified liposomal formulations of patupilone (EPO906)

BACKGROUND: Patupilone (EPO906) is a microtubule stabilizer with a potent antitumor effect. Integrin αVβ3-binding (RGD) liposomes were loaded with EPO906, and their antitumor efficacy was evaluated in two pediatric tumor models, ie, neuroblastoma and rhabdomyosarcoma. METHODS: Integrin αVβ3 gene exp...

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Bibliografiska uppgifter
Huvudupphovsmän: Scherzinger-Laude, Karine, Schönherr, Carina, Lewrick, Felicitas, Süss, Regine, Francese, Giancarlo, Rössler, Jochen
Materialtyp: Artigo
Språk:Inglês
Publicerad: Dove Medical Press 2013
Ämnen:
Original Research
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3693827/
https://ncbi.nlm.nih.gov/pubmed/23818777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S44025
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