The Nrf2 Activator Oltipraz Also Activates the Constitutive Androstane Receptor

Oltipraz (OPZ) is a well known inducer of NAD(P)H:quinone oxidoreductase (NQO1) along with other enzymes that comprise the nuclear factor E2-related factor 2 (Nrf2) battery of detoxification genes. However, OPZ treatment also induces expression of CYP2B, a gene regulated by the constitutive androsta...

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Detalhes bibliográficos
Main Authors: Merrell, Matthew D., Jackson, Jonathan P., Augustine, Lisa M., Fisher, Craig D., Slitt, Angela L., Maher, Jonathan M., Huang, Wendong, Moore, David D., Zhang, Youcai, Klaassen, Curtis D., Cherrington, Nathan J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3693743/
https://ncbi.nlm.nih.gov/pubmed/18474683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.108.020867
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