Low-Level Domoic Acid Protects Mouse Cerebellar Granule Neurons from Acute Neurotoxicity: Role of Glutathione

Domoic acid (DomA) is a potent marine neurotoxin. By activating α-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid/kainate receptors, DomA induces oxidative stress–mediated apoptotic cell death in neurons. The effect of prolonged (10 days) exposure to a low, nontoxic concentration (5nM) of DomA o...

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Main Authors: Giordano, Gennaro, Kavanagh, Terrance J., Faustman, Elaine M., White, Collin C., Costa, Lucio G.
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2013
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3693515/
https://ncbi.nlm.nih.gov/pubmed/23315585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kft002
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