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Apoptosis induced by domoic acid in mouse cerebellar granule neurons involves activation of p38 and JNK MAP kinases

In mouse cerebellar granule neurons (CGN) the marine neurotoxin domoic acid (DomA) induces neuronal cell death, either by apoptosis or by necrosis, depending on its concentration, with apoptotic damage predominating in response to low concentrations (100 nM). DomA-induced apoptosis is due to selecti...

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Detalhes bibliográficos
Main Authors: Giordano, G., Klintworth, H.M., Kavanagh, T.J., Costa, L.G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2394507/
https://ncbi.nlm.nih.gov/pubmed/18164102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuint.2007.11.004
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