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Effects of Pharmacokinetic Processes and Varied Dosing Schedules on the Dynamics of Acquired Resistance to Erlotinib in EGFR-Mutant Lung Cancer

INTRODUCTION: Erlotinib (Tarceva) is an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, which effectively targets EGFR-mutant driven non–small-cell lung cancer. However, the evolution of acquired resistance because of a second-site mutation (T790M) within EGFR remains an obstacle...

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Bibliografiske detaljer
Main Authors: Foo, Jasmine, Chmielecki, Juliann, Pao, William, Michor, Franziska
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3693219/
https://ncbi.nlm.nih.gov/pubmed/22982659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/JTO.0b013e31826146ee
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