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Does CALU SNP rs1043550 Contribute Variability to Therapeutic Warfarin Dosing Requirements?
OBJECTIVES: Calumenin, a molecular chaperone, exerts a regulatory effect on the vitamin K-dependent γ-carboxylation redox cycle that inhibits transfer of the reduced vitamin K from VKORC1, the pharmacological target of warfarin, to the γ-carboxylase. Because of its polymorphic structure and central...
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| Autores principales: | , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Marshfield Clinic
2013
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| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3692386/ https://ncbi.nlm.nih.gov/pubmed/23656803 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3121/cmr.2013.1130 |
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