Does CALU SNP rs1043550 Contribute Variability to Therapeutic Warfarin Dosing Requirements?

OBJECTIVES: Calumenin, a molecular chaperone, exerts a regulatory effect on the vitamin K-dependent γ-carboxylation redox cycle that inhibits transfer of the reduced vitamin K from VKORC1, the pharmacological target of warfarin, to the γ-carboxylase. Because of its polymorphic structure and central...

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Bibliographic Details
Main Authors: Glurich, Ingrid, Berg, Richard L., Burmester, James K.
Format: Artigo
Language:Inglês
Published: Marshfield Clinic 2013
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Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3692386/
https://ncbi.nlm.nih.gov/pubmed/23656803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3121/cmr.2013.1130
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