Genetic Basis of Hypersusceptibility to Protease Inhibitors and Low Replicative Capacity of Human Immunodeficiency Virus Type 1 Strains in Primary Infection

The initial virus strains from as many as 12% of individuals with primary human immunodeficiency virus (HIV) infection have a 50% inhibitory concentration ≤0.4-fold that of HIV type 1(NL4-3) (HIV-1(NL4-3)) to ritonavir (hypersusceptibility [HS]). There is also substantial variation in replicative ca...

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Main Authors: Leigh Brown, Andrew J., Frost, Simon D. W., Good, Benjamin, Daar, Eric S., Simon, Viviana, Markowitz, Martin, Collier, Ann C., Connick, Elizabeth, Conway, Brian, Margolick, Joseph B., Routy, Jean-Pierre, Corbeil, Jacques, Hellmann, Nicholas S., Richman, Douglas D., Little, Susan J.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2004
Assuntos:
Vaccines and Antiviral Agents
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC369210/
https://ncbi.nlm.nih.gov/pubmed/14963120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.5.2242-2246.2004
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