Unselected Mutations in the Human Immunodeficiency Virus Type 1 Genome Are Mostly Nonsynonymous and Often Deleterious

Mutation rates of human immunodeficiency virus type 1 (HIV-1) genomes have been estimated using purified reverse transcriptase or single-round infection system. Since small sequences were used as templates, the overall mutation rates could only be extrapolated and the biological significance of muta...

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Detalhes bibliográficos
Main Authors: Gao, Feng, Chen, Yalu, Levy, David N., Conway, Joan A., Kepler, Thomas B., Hui, Huxiong
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Recombination and Evolution
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC369203/
https://ncbi.nlm.nih.gov/pubmed/14963138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.5.2426-2433.2004
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