Unselected Mutations in the Human Immunodeficiency Virus Type 1 Genome Are Mostly Nonsynonymous and Often Deleterious

Mutation rates of human immunodeficiency virus type 1 (HIV-1) genomes have been estimated using purified reverse transcriptase or single-round infection system. Since small sequences were used as templates, the overall mutation rates could only be extrapolated and the biological significance of muta...

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Bibliografiske detaljer
Udgivet i:J Virol
Main Authors: Gao, Feng, Chen, Yalu, Levy, David N., Conway, Joan A., Kepler, Thomas B., Hui, Huxiong
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2004
Fag:
Recombination and Evolution
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC369203/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14963138/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.78.5.2426-2433.2004
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