Blocking of α4β7 Gut-Homing Integrin during Acute Infection Leads to Decreased Plasma and Gastrointestinal Tissue Viral Loads in Simian Immunodeficiency Virus-Infected Rhesus Macaques

Intravenous administration of a novel recombinant rhesus mAb against the α4β7 gut-homing integrin (mAb) into rhesus macaques just prior to and during acute SIV infection resulted in significant decrease in plasma and gastrointestinal (GI) tissue viral load and a marked reduction in GI tissue provira...

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Bibliografiset tiedot
Päätekijät: Ansari, Aftab A., Reimann, Keith A., Mayne, Ann E., Takahashi, Yoshiaki, Stephenson, Susan T., Wang, Rijian, Wang, Xinyue, Li, Jichu, Price, Andrew A., Little, Dawn M., Zaidi, Mohammad, Lyles, Robert, Villinger, Francois
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2010
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3691699/
https://ncbi.nlm.nih.gov/pubmed/21149598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1003052
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