Time-dependent changes in gene expression induced by secreted amyloid precursor protein-alpha in the rat hippocampus

BACKGROUND: Differential processing of the amyloid precursor protein liberates either amyloid-ß, a causative agent of Alzheimer’s disease, or secreted amyloid precursor protein-alpha (sAPPα), which promotes neuroprotection, neurotrophism, neurogenesis and synaptic plasticity. The underlying molecula...

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Bibliografiske detaljer
Main Authors: Ryan, Margaret M, Morris, Gary P, Mockett, Bruce G, Bourne, Katie, Abraham, Wickliffe C, Tate, Warren P, Williams, Joanna M
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3691674/
https://ncbi.nlm.nih.gov/pubmed/23742273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-14-376
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