Radiotherapy plus nimotuzumab or placebo in the treatment of high grade glioma patients: results from a randomized, double blind trial

BACKGROUND: The prognosis of patients bearing high grade glioma remains dismal. Epidermal Growth Factor Receptor (EGFR) is well validated as a primary contributor of glioma initiation and progression. Nimotuzumab is a humanized monoclonal antibody that recognizes the EGFR extracellular domain and re...

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Bibliografiske detaljer
Main Authors: Solomón, Maria Teresa, Selva, Julio César, Figueredo, Javier, Vaquer, José, Toledo, Carolina, Quintanal, Nelson, Salva, Silvia, Domíngez, Rafael, Alert, José, Marinello, Jorge Juan, Catalá, Mauricio, Griego, Martha González, Martell, Juan Antonio, Luaces, Patricia Lorenzo, Ballesteros, Javier, de-Castro, Niurys, Bach, Ferdinand, Crombet, Tania
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3691625/
https://ncbi.nlm.nih.gov/pubmed/23782513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-13-299
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