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Methylation kinetics and CpG-island methylator phenotyope status in colorectal cancer cell lines

BACKGROUND: Hypermethylation of CpG islands is thought to contribute to carcinogenesis through the inactivation of tumor suppressor genes. Tumor cells with relatively high levels of CpG island methylation are considered CpG island methylator phenotypes (CIMP). The mechanisms that are responsible for...

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Main Authors: Wodarz, Dominik, Boland, C Richard, Goel, Ajay, Komarova, Natalia L
格式: Artigo
語言:Inglês
出版: BioMed Central 2013
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3691599/
https://ncbi.nlm.nih.gov/pubmed/23758948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1745-6150-8-14
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