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Genome-wide discovery of genetic variants affecting tamoxifen sensitivity and their clinical and functional validation
BACKGROUND: Beyond estrogen receptor (ER), there are no validated predictors for tamoxifen (TAM) efficacy and toxicity. We utilized a genome-wide cell-based model to comprehensively evaluate genetic variants for their contribution to cellular sensitivity to TAM. DESIGN: Our discovery model incorpora...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3690911/ https://ncbi.nlm.nih.gov/pubmed/23508821 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/annonc/mdt125 |
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