Targeting of the MNK–eIF4E axis in blast crisis chronic myeloid leukemia inhibits leukemia stem cell function

Chronic myeloid leukemia responds well to therapy targeting the oncogenic fusion protein BCR-ABL1 in chronic phase, but is resistant to treatment after it progresses to blast crisis (BC). BC is characterized by elevated β-catenin signaling in granulocyte macrophage progenitors (GMPs), which enables...

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Detalhes bibliográficos
Main Authors: Lim, Sharon, Saw, Tzuen Yih, Zhang, Min, Janes, Matthew R., Nacro, Kassoum, Hill, Jeffrey, Lim, An Qi, Chang, Chia-Tien, Fruman, David A., Rizzieri, David A., Tan, Soo Yong, Fan, Hung, Chuah, Charles T. H., Ong, S. Tiong
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3690864/
https://ncbi.nlm.nih.gov/pubmed/23737503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1301838110
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