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Simulating the pulling of stalled elongated peptide from the ribosome by the translocon

The nature of the coupling between the stalling of the elongated nascent peptide chain in the ribosome and its insertion through the translocon is analyzed, focusing on the recently discovered biphasic force that overcomes the stalling barrier. The origin of this long-range coupling is explored by c...

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Detalhes bibliográficos
Main Authors: Rychkova, Anna, Mukherjee, Shayantani, Bora, Ram Prasad, Warshel, Arieh
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3690858/
https://ncbi.nlm.nih.gov/pubmed/23729811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1307869110
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