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EZH2 inhibition decreases p38 signaling and suppresses breast cancer motility and metastasis

EZH2 is a Polycomb group protein that exerts oncogenic functions in breast cancer, where its overexpression is associated with metastatic disease. While it reportedly acts a transcriptional repressor through trimethylation of histone H3 at lysine 27, EZH2 may exhibit context-dependent activating fun...

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Detalhes bibliográficos
Main Authors: Moore, Heather M., Gonzalez, Maria E., Toy, Kathy A., Cimino-Mathews, Ashley, Argani, Pedram, Kleer, Celina G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3690767/
https://ncbi.nlm.nih.gov/pubmed/23539298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10549-013-2498-x
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