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EZH2 inhibition decreases p38 signaling and suppresses breast cancer motility and metastasis
EZH2 is a Polycomb group protein that exerts oncogenic functions in breast cancer, where its overexpression is associated with metastatic disease. While it reportedly acts a transcriptional repressor through trimethylation of histone H3 at lysine 27, EZH2 may exhibit context-dependent activating fun...
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| Main Authors: | , , , , , |
|---|---|
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3690767/ https://ncbi.nlm.nih.gov/pubmed/23539298 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10549-013-2498-x |
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