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Enhanced Sampling and Overfitting Analyses in Structural Refinement of Nucleic Acids into Electron Microscopy Maps

Flexible-fitting computational algorithms are often useful to interpret low resolution maps of many macromolecular complexes generated by electron microscopy (EM) imaging. One such atomistic simulation technique is molecular dynamics flexible fitting (MDFF), which has been widely applied to generate...

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Detalhes bibliográficos
Main Authors: Vashisth, Harish, Skiniotis, Georgios, Brooks, Charles L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3690198/
https://ncbi.nlm.nih.gov/pubmed/23506287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jp3126297
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