Antidepressant Treatment Reduces Serotonin-1A Autoreceptor Binding in Major Depressive Disorder

BACKGROUND: Chronic selective serotonin reuptake inhibitor (SSRI) administration to rodents desensitizes or downregulates raphe 5-HT(1A) autoreceptors. We previously found elevated 5-HT(1A) binding in antidepressant-naïve and not recently-medicated major depressive disorder, and now report the effec...

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Main Authors: Gray, Neil A., Milak, Matthew S., DeLorenzo, Christine, Ogden, R. Todd, Huang, Yung-yu, Mann, J. John, Parsey, Ramin V.
Formato: Artigo
Idioma:Inglês
Publicado: 2013
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3690146/
https://ncbi.nlm.nih.gov/pubmed/23374637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2012.11.012
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