The Val158Met polymorphism of the COMT gene is associated with increased pain sensitivity in morphine-treated patients undergoing a painful procedure after cardiac surgery

AIMS: The catechol-O-methyltransferase (COMT) Val158Met polymorphism affected pain sensitivity of healthy volunteers upon application of experimental pain stimuli. The relevance of these findings in morphine-treated postoperative cardiac patients undergoing painful healthcare procedures is unknown;...

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Main Authors: Ahlers, Sabine J G M, Elens, Laure L, van Gulik, Laura, van Schaik, Ron H, van Dongen, Eric P A, Bruins, Peter, Tibboel, Dick, Knibbe, Catherijne A J
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2013
Assuntos:
Pharmacogenetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3690109/
https://ncbi.nlm.nih.gov/pubmed/23210659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12052
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