In Silico Screening on the Three-dimensional Model of the Plasmodium vivax SUB1 Protease Leads to the Validation of a Novel Anti-parasite Compound

Widespread drug resistance calls for the urgent development of new antimalarials that target novel steps in the life cycle of Plasmodium falciparum and Plasmodium vivax. The essential subtilisin-like serine protease SUB1 of Plasmodium merozoites plays a dual role in egress from and invasion into hos...

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Detalhes bibliográficos
Main Authors: Bouillon, Anthony, Giganti, David, Benedet, Christophe, Gorgette, Olivier, Pêtres, Stéphane, Crublet, Elodie, Girard-Blanc, Christine, Witkowski, Benoit, Ménard, Didier, Nilges, Michael, Mercereau-Puijalon, Odile, Stoven, Véronique, Barale, Jean-Christophe
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Computational Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3689996/
https://ncbi.nlm.nih.gov/pubmed/23653352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.456764
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