Selective Metabolism of Hypothiocyanous Acid by Mammalian Thioredoxin Reductase Promotes Lung Innate Immunity and Antioxidant Defense

The endogenously produced oxidant hypothiocyanous acid (HOSCN) inhibits and kills pathogens but paradoxically is well tolerated by mammalian host tissue. Mammalian high molecular weight thioredoxin reductase (H-TrxR) is evolutionarily divergent from bacterial low molecular weight thioredoxin reducta...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Chandler, Joshua D., Nichols, David P., Nick, Jerry A., Hondal, Robert J., Day, Brian J.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2013
Gaiak:
Enzymology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3689984/
https://ncbi.nlm.nih.gov/pubmed/23629660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.468090
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