Stability of the Endosomal Scaffold Protein LAMTOR3 Depends on Heterodimer Assembly and Proteasomal Degradation

LAMTOR3 (MP1) and LAMTOR2 (p14) form a heterodimer as part of the larger Ragulator complex that is required for MAPK and mTOR1 signaling from late endosomes/lysosomes. Here, we show that loss of LAMTOR2 (p14) results in an unstable cytosolic monomeric pool of LAMTOR3 (MP1). Monomeric cytoplasmic LAM...

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Bibliographische Detailangaben
Hauptverfasser: de Araújo, Mariana E. G., Stasyk, Taras, Taub, Nicole, Ebner, Hannes L., Fürst, Beatrix, Filipek, Przemyslaw, Weys, Sabine R., Hess, Michael W., Lindner, Herbert, Kremser, Leopold, Huber, Lukas A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2013
Schlagworte:
Signal Transduction
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3689965/
https://ncbi.nlm.nih.gov/pubmed/23653355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.349480
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