Insulin and IGF-I Inhibit GH Synthesis and Release in Vitro and in Vivo by Separate Mechanisms

IGF-I is considered a primary inhibitor of GH secretion. Insulin may also play an important role in regulating GH levels because insulin, like IGF-I, can suppress GH synthesis and release in primary pituitary cell cultures and insulin is negatively correlated with GH levels in vivo. However, underst...

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Main Authors: Gahete, Manuel D., Córdoba-Chacón, José, Lin, Qing, Brüning, Jens C., Kahn, C. Ronald, Castaño, Justo P., Christian, Helen, Luque, Raúl M., Kineman, Rhonda D.
Formato: Artigo
Idioma:Inglês
Publicado: Endocrine Society 2013
Assuntos:
Growth Hormone-Somatostatin-GRH
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3689283/
https://ncbi.nlm.nih.gov/pubmed/23671263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2013-1261
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