An integrated multidisciplinary model describing initiation of cancer and the Warburg hypothesis

BACKGROUND: In this paper we propose a chemical physics mechanism for the initiation of the glycolytic switch commonly known as the Warburg hypothesis, whereby glycolytic activity terminating in lactate continues even in well-oxygenated cells. We show that this may result in cancer via mitotic failu...

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Autors principals: Rietman, Edward A, Friesen, Douglas E, Hahnfeldt, Philip, Gatenby, Robert, Hlatky, Lynn, Tuszynski, Jack A
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2013
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3689044/
https://ncbi.nlm.nih.gov/pubmed/23758735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4682-10-39
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