Inhibition of cyclooxygenase-2-dependent survivin mediates decursin-induced apoptosis in human KBM-5 myeloid leukemia cells

We demonstrate that decursin induces apoptosis via regulation of cyclooxygenase-2 (COX-2) and survivin in leukemic KBM-5 cells. By activating an apoptotic machinery, decursin is cytotoxic to KBM-5 cells. In this apoptotic process, decursin can activate caspase family members and triggers PARP cleava...

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Autori principali: Ahn, Quein, Jeong, Soo-Jin, Lee, Hyo-Jung, Kwon, Hee-Young, Han, Ihn, Kim, Hyun Seok, Lee, Hyo-Jeong, Lee, Eun-Ok, Ahn, Kwang Seok, Jung, Min-Hyung, Zhu, Shudong, Chen, Chang-Yan, Kim, Sung-Hoon
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3689030/
https://ncbi.nlm.nih.gov/pubmed/20673699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2010.07.007
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