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Structural Insights into the Folding Defects of Oncogenic pVHL Lead to Correction of Its Function In Vitro
Loss of function mutations in the von Hippel-Lindau (pVHL) tumor suppressor protein are tumorigenic. In silico analysis of the structure and folding of WT pVHL identified in its core an aromatic tetrahedron, essential for stabilizing the protein. The mutations disrupt the aromatic tetrahedron, leadi...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3688787/ https://ncbi.nlm.nih.gov/pubmed/23840444 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0066333 |
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