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Heme Oxygenase-1 Regulates Matrix Metalloproteinase MMP-1 Secretion and Chondrocyte Cell Death via Nox4 NADPH Oxidase Activity in Chondrocytes

Interleukin-1β (IL-1β) activates the production of reactive oxygen species (ROS) and secretion of MMPs as well as chondrocyte apoptosis. Those events lead to matrix breakdown and are key features of osteoarthritis (OA). We confirmed that in human C-20/A4 chondrocytes the NADPH oxidase Nox4 is the ma...

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Detalhes bibliográficos
Main Authors: Rousset, Francis, Nguyen, Minh Vu Chuong, Grange, Laurent, Morel, Françoise, Lardy, Bernard
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3688771/
https://ncbi.nlm.nih.gov/pubmed/23840483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0066478
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