The novel 13S,14S-epoxy-maresin is converted by human macrophages to maresin 1 (MaR1), inhibits leukotriene A(4) hydrolase (LTA(4)H), and shifts macrophage phenotype

Maresins are produced by macrophages from docosahexaenoic acid (DHA) and exert potent proresolving and tissue homeostatic actions. Maresin 1 (MaR1; 7R,14S-dihydroxy-docosa-4Z,8E,10E,12Z,16Z,19Z-hexaenoic acid) is the first identified maresin. Here, we investigate formation, stereochemistry, and prec...

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Detalhes bibliográficos
Main Authors: Dalli, Jesmond, Zhu, Min, Vlasenko, Nikita A., Deng, Bin, Haeggström, Jesper Z., Petasis, Nicos A., Serhan, Charles N.
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2013
Assuntos:
Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3688739/
https://ncbi.nlm.nih.gov/pubmed/23504711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.13-227728
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