IGHV1-69-Encoded Antibodies Expressed in Chronic Lymphocytic Leukemia React with Malondialdehyde–Acetaldehyde Adduct, an Immunodominant Oxidation-Specific Epitope

The immunoglobulins expressed by chronic lymphocytic leukemia (CLL) B cells are highly restricted, suggesting they are selected for binding either self or foreign antigen. Of the immunoglobulin heavy-chain variable (IGHV) genes expressed in CLL, IGHV1-69 is the most common, and often is expressed wi...

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Main Authors: Que, Xuchu, Widhopf II, George F., Amir, Shahzada, Hartvigsen, Karsten, Hansen, Lotte F., Woelkers, Douglas, Tsimikas, Sotirios, Binder, Christoph J., Kipps, Thomas J., Witztum, Joseph L.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2013
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3688726/
https://ncbi.nlm.nih.gov/pubmed/23840319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0065203
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