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The N-Terminal Domains of Vps3 and Vps8 Are Critical for Localization and Function of the CORVET Tethering Complex on Endosomes

Endosomal biogenesis depends on multiple fusion and fission events. For fusion, the heterohexameric CORVET complex as an effector of the endosomal Rab5/Vps21 GTPase has a central function in the initial tethering event. Here, we show that the CORVET-specific Vps3 and Vps8 subunits, which interact wi...

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Bibliographische Detailangaben
Hauptverfasser: Epp, Nadine, Ungermann, Christian
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3688683/
https://ncbi.nlm.nih.gov/pubmed/23840658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0067307
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