Nitric Oxide Synthase Dysfunction Contributes to Impaired Cerebroarteriolar Reactivity in Experimental Cerebral Malaria

Cerebrovascular dysfunction plays a key role in the pathogenesis of cerebral malaria. In experimental cerebral malaria (ECM) induced by Plasmodium berghei ANKA, cerebrovascular dysfunction characterized by vascular constriction, occlusion and damage results in impaired perfusion and reduced cerebral...

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Bibliographic Details
Main Authors: Ong, Peng Kai, Melchior, Benoît, Martins, Yuri C., Hofer, Anthony, Orjuela-Sánchez, Pamela, Cabrales, Pedro, Zanini, Graziela M., Frangos, John A., Carvalho, Leonardo J. M.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3688552/
https://ncbi.nlm.nih.gov/pubmed/23818850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003444
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