Loss of Catalytically Inactive Lipid Phosphatase Myotubularin-related Protein 12 Impairs Myotubularin Stability and Promotes Centronuclear Myopathy in Zebrafish

X-linked myotubular myopathy (XLMTM) is a congenital disorder caused by mutations of the myotubularin gene, MTM1. Myotubularin belongs to a large family of conserved lipid phosphatases that include both catalytically active and inactive myotubularin-related proteins (i.e., “MTMRs”). Biochemically, c...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Gupta, Vandana A., Hnia, Karim, Smith, Laura L., Gundry, Stacey R., McIntire, Jessica E., Shimazu, Junko, Bass, Jessica R., Talbot, Ethan A., Amoasii, Leonela, Goldman, Nathaniel E., Laporte, Jocelyn, Beggs, Alan H.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2013
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3688503/
https://ncbi.nlm.nih.gov/pubmed/23818870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003583
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires