Loss of Catalytically Inactive Lipid Phosphatase Myotubularin-related Protein 12 Impairs Myotubularin Stability and Promotes Centronuclear Myopathy in Zebrafish

X-linked myotubular myopathy (XLMTM) is a congenital disorder caused by mutations of the myotubularin gene, MTM1. Myotubularin belongs to a large family of conserved lipid phosphatases that include both catalytically active and inactive myotubularin-related proteins (i.e., “MTMRs”). Biochemically, c...

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Αποθηκεύτηκε σε:
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Κύριοι συγγραφείς: Gupta, Vandana A., Hnia, Karim, Smith, Laura L., Gundry, Stacey R., McIntire, Jessica E., Shimazu, Junko, Bass, Jessica R., Talbot, Ethan A., Amoasii, Leonela, Goldman, Nathaniel E., Laporte, Jocelyn, Beggs, Alan H.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Public Library of Science 2013
Θέματα:
Research Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3688503/
https://ncbi.nlm.nih.gov/pubmed/23818870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003583
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