Loss of Catalytically Inactive Lipid Phosphatase Myotubularin-related Protein 12 Impairs Myotubularin Stability and Promotes Centronuclear Myopathy in Zebrafish

X-linked myotubular myopathy (XLMTM) is a congenital disorder caused by mutations of the myotubularin gene, MTM1. Myotubularin belongs to a large family of conserved lipid phosphatases that include both catalytically active and inactive myotubularin-related proteins (i.e., “MTMRs”). Biochemically, c...

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Главные авторы: Gupta, Vandana A., Hnia, Karim, Smith, Laura L., Gundry, Stacey R., McIntire, Jessica E., Shimazu, Junko, Bass, Jessica R., Talbot, Ethan A., Amoasii, Leonela, Goldman, Nathaniel E., Laporte, Jocelyn, Beggs, Alan H.
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2013
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3688503/
https://ncbi.nlm.nih.gov/pubmed/23818870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003583
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