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First demonstration that brain CYP2D-mediated opiate metabolic activation alters analgesia in vivo
The response to centrally-acting drugs is highly variable between individuals and does not always correlate with plasma drug levels. Drug-metabolizing CYP enzymes in the brain may contribute to this variability by affecting local drug and metabolite concentrations. CYP2D metabolizes codeine to the a...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3687523/ https://ncbi.nlm.nih.gov/pubmed/23623752 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2013.04.014 |
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