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Altered Cholesterol Homeostasis in Aged Macrophages Linked to Neovascular Macular Degeneration
Abnormal lipid metabolism has been linked to age-related macular degeneration (AMD); choroidal neovascularization in late AMD commonly causes blindness. Sene et al. (2013) now demonstrate that in aged macrophages decreased ABCA1 expression, regulated by liver X receptor and miR-33, impairs export of...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3687521/ https://ncbi.nlm.nih.gov/pubmed/22561819 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2761 |
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