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Altered Cholesterol Homeostasis in Aged Macrophages Linked to Neovascular Macular Degeneration

Abnormal lipid metabolism has been linked to age-related macular degeneration (AMD); choroidal neovascularization in late AMD commonly causes blindness. Sene et al. (2013) now demonstrate that in aged macrophages decreased ABCA1 expression, regulated by liver X receptor and miR-33, impairs export of...

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Autors principals: Chen, Jing, Smith, Lois E.H.
Format: Artigo
Idioma:Inglês
Publicat: 2012
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3687521/
https://ncbi.nlm.nih.gov/pubmed/22561819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2761
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