MiR-21/Smad 7 signaling determines TGF-β1-induced CAF formation

How TGF-β1-mediated signaling pathways are finely tuned to orchestrate the generation of carcinoma-associated fibroblasts (CAFs) is poorly understood. Here, we demonstrate that miR-21 and the signaling of its target Smad 7 determine TGF-β1-induced CAF formation. In primary cultured fibroblasts, matu...

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Bibliografiske detaljer
Main Authors: Li, Qiong, Zhang, Daoxiang, Wang, Yongbin, Sun, Pan, Hou, Xiaodan, Larner, James, Xiong, Wujun, Mi, Jun
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3687228/
https://ncbi.nlm.nih.gov/pubmed/23784029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep02038
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