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MiR-21/Smad 7 signaling determines TGF-β1-induced CAF formation
How TGF-β1-mediated signaling pathways are finely tuned to orchestrate the generation of carcinoma-associated fibroblasts (CAFs) is poorly understood. Here, we demonstrate that miR-21 and the signaling of its target Smad 7 determine TGF-β1-induced CAF formation. In primary cultured fibroblasts, matu...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3687228/ https://ncbi.nlm.nih.gov/pubmed/23784029 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep02038 |
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