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The constant region affects antigen binding of antibodies to DNA by altering secondary structure
We previously demonstrated an important role of the constant region in the pathogenicity of anti-DNA antibodies. To determine the mechanisms by which the constant region affects autoantibody binding, a panel of isotype–switch variants (IgG1, IgG2a, IgG2b) was generated from the murine PL9-11 IgG3 au...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2013
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3687031/ https://ncbi.nlm.nih.gov/pubmed/23665381 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molimm.2013.04.004 |
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