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The constant region contributes to the antigenic specificity and renal pathogenicity of murine anti-DNA antibodies
Affinity for DNA and cross-reactivity with renal antigens are associated with enhanced renal pathogenicity of lupus autoantibodies. In addition, certain IgG subclasses are enriched in nephritic kidneys, suggesting that isotype may determine the outcome of antibody binding to renal antigens. To inves...
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| Main Authors: | , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3656415/ https://ncbi.nlm.nih.gov/pubmed/22841793 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaut.2012.06.005 |
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