p27 Suppresses Cyclooxygenase-2 Expression by Inhibiting p38β and p38δ-Mediated CREB Phosphorylation Upon Arsenite Exposure

p27 is a cyclin-dependent kinase (CDK) inhibitor that suppresses a cell’s transition from G(0) to S phase, therefore acting as a tumor suppressor. Our most recent studies demonstrate that upon arsenite exposure, p27 suppresses Hsp27 and Hsp70 expressions through the JNK2/c-Jun- and HSF-1-dependent p...

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Detalhes bibliográficos
Main Authors: Che, Xun, Liu, Jinyi, Huang, Haishan, Mi, Xiaoyi, Xia, Qing, Li, Jingxia, Zhang, Dongyun, Ke, Qingdong, Gao, Jimin, Huang, Chuanshu
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3686879/
https://ncbi.nlm.nih.gov/pubmed/23639288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamcr.2013.04.012
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