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CYP3A4*22 genotype and systemic exposure affect paclitaxel-induced neurotoxicity
PURPOSE: Paclitaxel is used for the treatment of several solid tumors and displays a high inter-individual variation in exposure and toxicity. Neurotoxicity is one of the most prominent side-effects of paclitaxel. This study explores potential predictive pharmacokinetic and pharmacogenetic determina...
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Hlavní autoři: | , , , , , , , , , , , , , |
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Médium: | Artigo |
Jazyk: | Inglês |
Vydáno: |
2013
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Témata: | |
On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3686845/ https://ncbi.nlm.nih.gov/pubmed/23640974 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-12-3786 |
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