Genetic Variants of Pregnane X Receptor (PXR) and CYP2B6 Affect the Induction of Bupropion Hydroxylation by Sodium Ferulate

This study investigated the effects of pregnane X receptor (PXR/NR1I2) and CYP2B6 genetic variants on sodium ferulate (SF)-mediated induction of bupropion hydroxylation. The pharmacokinetics of bupropion and hydroxybupropion were evaluated after an oral dose of bupropion (150 mg) administered with a...

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Autors principals: Gao, Lichen, He, Yijing, Tang, Jie, Yin, Jiye, Huang, Zhengyu, Liu, Fangqun, Ouyang, Dongsheng, Chen, Xiaoping, Zhang, Wei, Liu, Zhaoqian, Zhou, Honghao
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2013
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3686783/
https://ncbi.nlm.nih.gov/pubmed/23840296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0062489
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