Pharmacologic Approach to Defective Protein Trafficking in the E637K-hERG Mutant with PD-118057 and Thapsigargin

BACKGROUND: Treatment of LQT2 is inadequate. Many drugs which can pharmacologically rescue defective protein trafficking in LQT2 also result in potent blockade of HERG current, negating their therapeutic benefit. It is reported that PD-118057 and thapsigargin can rescue LQT2 without hERG channel blo...

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Main Authors: Mao, Haiyan, Lu, Xiaoli, Karush, Justin Michael, Huang, Xiaoyan, Yang, Xi, Ba, Yanna, Wang, Ying, Liu, Ningsheng, Zhou, Jianqing, Lian, Jiangfang
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2013
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3686757/
https://ncbi.nlm.nih.gov/pubmed/23840331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0065481
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