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Is the Amyloid Hypothesis of Alzheimer's disease therapeutically relevant?

The conventional view of AD (Alzheimer's disease) is that much of the pathology is driven by an increased load of β-amyloid in the brain of AD patients (the ‘Amyloid Hypothesis’). Yet, many therapeutic strategies based on lowering β-amyloid have so far failed in clinical trials. This failure of...

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Bibliografiska uppgifter
Huvudupphovsmän: Teich, Andrew F., Arancio, Ottavio
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2012
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3686157/
https://ncbi.nlm.nih.gov/pubmed/22891628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20120653
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