Evolution of chromosomal regions containing transfected and amplified dihydrofolate reductase sequences.
A modular dihydrofolate reductase gene has been introduced into Chinese hamster ovary cells lacking dihydrofolate reductase. Clones capable of growth in the absence of added nucleosides contain one to five copies of the plasmid DNA integrated into the host genome. Upon stepwise selection to increasi...
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| Publicado no: | Mol Cell Biol |
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| Principais autores: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Taylor & Francis
1983
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC368586/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6855772/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.3.4.699-711.1983 |
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