Evolution of chromosomal regions containing transfected and amplified dihydrofolate reductase sequences.

A modular dihydrofolate reductase gene has been introduced into Chinese hamster ovary cells lacking dihydrofolate reductase. Clones capable of growth in the absence of added nucleosides contain one to five copies of the plasmid DNA integrated into the host genome. Upon stepwise selection to increasi...

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Veröffentlicht in:	Mol Cell Biol
Hauptverfasser:	Kaufman, R J, Sharp, P A, Latt, S A
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Taylor & Francis 1983
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC368586/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6855772/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.3.4.699-711.1983
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