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Modulation of 5-Lipoxygenase in Proteotoxicity and Alzheimer's Disease
The accumulation of intracellular β amyloid (Aβ) may be one of the factors leading to neuronal cell death in Alzheimer's disease (AD). Using a pyrazole called CNB-001, which was selected for its ability to reduce intracellular Aβ, we show that the activation of the eIF2α/ATF4 arm of the unfolde...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Society for Neuroscience
2013
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3685841/ https://ncbi.nlm.nih.gov/pubmed/23785163 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5183-12.2013 |
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