In vitro methylation of specific regions of the cloned Moloney sarcoma virus genome inhibits its transforming activity.

The transforming activity of cloned Moloney sarcoma virus (MSV) proviral DNA was inhibited by in vitro methylation of the DNA at cytosine residues, using HpaII and HhaI methylases before transfection into NIH 3T3 cells. The inhibition of transforming activity due to HpaII methylation was reversed by...

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Veröffentlicht in:	Mol Cell Biol
Hauptverfasser:	McGeady, M L, Jhappan, C, Ascione, R, Vande Woude, G F
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Taylor & Francis 1983
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC368539/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6843547/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.3.3.305-314.1983
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