Pharmacodynamics of Liposomal Amphotericin B and Flucytosine for Cryptococcal Meningoencephalitis: Safe and Effective Regimens for Immunocompromised Patients

Background. Cryptococcal meningoencephalitis is a lethal infection with relatively few therapeutic options. The optimal dosage of liposomal amphotericin B (LAmB) alone or in combination with flucytosine is not known. Methods. A murine model of cryptococcal meningoencephalitis was used. The fungal de...

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Bibliographic Details
Main Authors: O'Connor, Lucy, Livermore, Joanne, Sharp, Andrew D., Goodwin, Joanne, Gregson, Lea, Howard, Susan J., Felton, Timothy W., Schwartz, Julie A., Neely, Michael N., Harrison, Thomas S., Perfect, John R., Hope, William W.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2013
Subjects:
Major Articles and Brief Reports
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3685229/
https://ncbi.nlm.nih.gov/pubmed/23599314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jit164
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